{"symbol":"CCDC22","synonyms":["RTSC2","JM1","CXORF37"],"name":"coiled-coil domain containing 22","description":"This gene encodes a protein containing a coiled-coil domain. The encoded protein functions in the regulation of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells) by interacting with COMMD (copper metabolism Murr1 domain-containing) proteins. The mouse orthologous protein has been shown to bind copines, which are calcium-dependent, membrane-binding proteins that may function in calcium signaling. This human gene has been identified as a novel candidate gene for syndromic X-linked intellectual disability. [provided by RefSeq, Aug 2013]","ncbiEntrezGeneId":28952,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/28952","proteins":[{"symbol":"CCD22_HUMAN","href":"/api/1.0/protein/CCD22_HUMAN"}],"hgncRootFamilies":[]}