{"symbol":"CCDC88A","synonyms":["GIRDIN","GIV","GRDN","HKRP1","KIAA1212","PEHOL"],"name":"coiled-coil domain containing 88A","description":"This gene encodes a member of the Girdin family of coiled-coil domain containing proteins. The encoded protein is an actin-binding protein that is activated by the serine/threonine kinase Akt and plays a role in cytoskeleton remodeling and cell migration. The encoded protein also enhances Akt signaling by mediating phosphoinositide 3-kinase (PI3K)-dependent activation of Akt by growth factor receptor tyrosine kinases and G protein-coupled receptors. Increased expression of this gene and phosphorylation of the encoded protein may play a role in cancer metastasis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]","ncbiEntrezGeneId":55704,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/55704","proteins":[{"symbol":"GRDN_HUMAN","href":"/api/1.0/protein/GRDN_HUMAN"}],"hgncRootFamilies":[]}