{"symbol":"CCL23","synonyms":["CKB-8","CKB-8-1","SCYA23","MIP3","HMRP-2A","CK-BETA-8","CKB8","MIP-3","MPIF-1"],"name":"chemokine (C-C motif) ligand 23","description":"This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, displays chemotactic activity on resting T lymphocytes and monocytes, lower activity on neutrophils and no activity on activated T lymphocytes. The protein is also a strong suppressor of colony formation by a multipotential hematopoietic progenitor cell line. In addition, the product of this gene is a potent agonist of the chemokine (C-C motif) receptor 1. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]","ncbiEntrezGeneId":6368,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6368","proteins":[{"symbol":"CCL23_HUMAN","href":"/api/1.0/protein/CCL23_HUMAN"}],"hgncRootFamilies":[{"name":"Chemokine ligands (CCL)","href":"/api/1.0/gene_family/Chemokine+ligands+%28CCL%29"},{"name":"Endogenous ligands","href":"/api/1.0/gene_family/Endogenous+ligands"}]}