{"symbol":"CCL5","synonyms":["SISD","TCP228","SIS-DELTA","D17S136E","EOCP","RANTES","SCYA5"],"name":"chemokine (C-C motif) ligand 5","description":"This gene is one of several chemokine genes clustered on the q-arm of chromosome 17. Chemokines form a superfamily of secreted proteins involved in immunoregulatory and inflammatory processes. The superfamily is divided into four subfamilies based on the arrangement of the N-terminal cysteine residues of the mature peptide. This chemokine, a member of the CC subfamily, functions as a chemoattractant for blood monocytes, memory T helper cells and eosinophils. It causes the release of histamine from basophils and activates eosinophils. This cytokine is one of the major HIV-suppressive factors produced by CD8+ cells. It functions as one of the natural ligands for the chemokine receptor chemokine (C-C motif) receptor 5 (CCR5), and it suppresses in vitro replication of the R5 strains of HIV-1, which use CCR5 as a coreceptor. Alternative splicing results in multiple transcript variants that encode different isoforms. [provided by RefSeq, Jul 2013]","ncbiEntrezGeneId":6352,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/6352","proteins":[{"symbol":"CCL5_HUMAN","href":"/api/1.0/protein/CCL5_HUMAN"}],"hgncRootFamilies":[{"name":"Chemokine ligands (CCL)","href":"/api/1.0/gene_family/Chemokine+ligands+%28CCL%29"},{"name":"Endogenous ligands","href":"/api/1.0/gene_family/Endogenous+ligands"}]}