{"symbol":"CCR2","synonyms":["CD192","MCP-1-R","CKR2","CKR2A","CKR2B","CCR2A","CMKBR2","CC-CKR-2","CCR2B","CCR-2"],"name":"chemokine (C-C motif) receptor 2","description":"The protein encoded by this gene is a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The encoded protein mediates agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This protein can also be a coreceptor with CD4 for HIV-1 infection. This gene is located in the chemokine receptor gene cluster region of chromosome 3. [provided by RefSeq, Aug 2017]","ncbiEntrezGeneId":729230,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/729230","proteins":[{"symbol":"CCR2_HUMAN","href":"/api/1.0/protein/CCR2_HUMAN"}],"hgncRootFamilies":[{"name":"G protein-coupled receptors","href":"/api/1.0/gene_family/G+protein-coupled+receptors"},{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"}]}