{"symbol":"CD247","synonyms":["CD3Z","CD3Q","T3Z","CD3-ZETA","IMD25","CD3H","TCRZ"],"name":"CD247 molecule","description":"The protein encoded by this gene is T-cell receptor zeta, which together with T-cell receptor alpha/beta and gamma/delta heterodimers, and with CD3-gamma, -delta and -epsilon, forms the T-cell receptor-CD3 complex. The zeta chain plays an important role in coupling antigen recognition to several intracellular signal-transduction pathways. Low expression of the antigen results in impaired immune response. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":919,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/919","proteins":[{"symbol":"CD3Z_HUMAN","href":"/api/1.0/protein/CD3Z_HUMAN"}],"hgncRootFamilies":[{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"}]}