{"symbol":"CD3D","synonyms":["T3D","IMD19","CD3-DELTA"],"name":"CD3d molecule, delta (CD3-TCR complex)","description":"The protein encoded by this gene is part of the T-cell receptor/CD3 complex (TCR/CD3 complex) and is involved in T-cell development and signal transduction. The encoded membrane protein represents the delta subunit of the CD3 complex, and along with four other CD3 subunits, binds either TCR alpha/beta or TCR gamma/delta to form the TCR/CD3 complex on the surface of T-cells. Defects in this gene are a cause of severe combined immunodeficiency autosomal recessive T-cell-negative/B-cell-positive/NK-cell-positive (SCIDBNK). Two transcript variants encoding different isoforms have been found for this gene. Other variants may also exist, but the full-length natures of their transcripts has yet to be defined. [provided by RefSeq, Feb 2009]","ncbiEntrezGeneId":915,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/915","proteins":[{"symbol":"CD3D_HUMAN","href":"/api/1.0/protein/CD3D_HUMAN"}],"hgncRootFamilies":[{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"}]}