{"symbol":"CD63","synonyms":["LAMP-3","MLA1","OMA81H","ME491","TSPAN30"],"name":"CD63 molecule","description":"The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. The encoded protein is a cell surface glycoprotein that is known to complex with integrins. It may function as a blood platelet activation marker. Deficiency of this protein is associated with Hermansky-Pudlak syndrome. Also this gene has been associated with tumor progression. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Apr 2012]","ncbiEntrezGeneId":967,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/967","proteins":[{"symbol":"CD63_HUMAN","href":"/api/1.0/protein/CD63_HUMAN"}],"hgncRootFamilies":[{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"},{"name":"Tetraspanins (TSPAN)","href":"/api/1.0/gene_family/Tetraspanins+%28TSPAN%29"}]}