{"symbol":"CD86","synonyms":["B7-2","B7.2","B70","LAB72","CD28LG2"],"name":"CD86 molecule","description":"This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]","ncbiEntrezGeneId":942,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/942","proteins":[{"symbol":"CD86_HUMAN","href":"/api/1.0/protein/CD86_HUMAN"}],"hgncRootFamilies":[{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"},{"name":"Immunoglobulin superfamily domain containing","href":"/api/1.0/gene_family/Immunoglobulin+superfamily+domain+containing"}]}