{"symbol":"CDH12","synonyms":["CDHB"],"name":"cadherin 12, type 2 (N-cadherin 2)","description":"This gene encodes a type II classical cadherin of the cadherin superfamily. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature cadherin protein. These integral membrane proteins mediate calcium-dependent cell-cell adhesion and are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) cadherins are defined based on their lack of a histidine-alanine-valine (HAV) cell adhesion recognition sequence specific to type I cadherins. This particular cadherin appears to be expressed specifically in the brain and its temporal pattern of expression would be consistent with a role during a critical period of neuronal development, perhaps specifically during synaptogenesis. [provided by RefSeq, Nov 2015]","ncbiEntrezGeneId":1010,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1010","proteins":[{"symbol":"CAD12_HUMAN","href":"/api/1.0/protein/CAD12_HUMAN"}],"hgncRootFamilies":[{"name":"Cadherins","href":"/api/1.0/gene_family/Cadherins"}]}