{"symbol":"CDH5","synonyms":["CD144","7B4"],"name":"cadherin 5, type 2 (vascular endothelium)","description":"This gene encodes a classical cadherin of the cadherin superfamily. The encoded preproprotein is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion molecule is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Functioning as a classical cadherin by imparting to cells the ability to adhere in a homophilic manner, this protein plays a role in endothelial adherens junction assembly and maintenance. This gene is located in a gene cluster in a region on the long arm of chromosome 16 that is involved in loss of heterozygosity events in breast and prostate cancer. [provided by RefSeq, Nov 2015]","ncbiEntrezGeneId":1003,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1003","proteins":[{"symbol":"CADH5_HUMAN","href":"/api/1.0/protein/CADH5_HUMAN"}],"hgncRootFamilies":[{"name":"Cadherins","href":"/api/1.0/gene_family/Cadherins"},{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"}]}