{"symbol":"CDK11B","synonyms":["P58CLK-1","CDC2L1","p58","CDK11","P58CDC2L1","CDK11-p58","PITSLREA","PK58","CLK-1","CDK11-p46","CDK11-p110"],"name":"cyclin-dependent kinase 11B","description":"This gene encodes a member of the serine/threonine protein kinase family. Members of this kinase family are known to be essential for eukaryotic cell cycle control. Due to a segmental duplication, this gene shares very high sequence identity with a neighboring gene. These two genes are frequently deleted or altered in neuroblastoma. The protein kinase encoded by this gene can be cleaved by caspases and may play a role in cell apoptosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]","ncbiEntrezGeneId":984,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/984","proteins":[{"symbol":"CD11B_HUMAN","href":"/api/1.0/protein/CD11B_HUMAN"}],"hgncRootFamilies":[{"name":"Cyclin-dependent kinases (CDK)","href":"/api/1.0/gene_family/Cyclin-dependent+kinases+%28CDK%29"}]}