{"symbol":"CDK12","synonyms":["CRKR","CRK7","CRKRS"],"name":"cyclin-dependent kinase 12","description":"Enables RNA polymerase II CTD heptapeptide repeat kinase activity and cyclin binding activity. Involved in several processes, including positive regulation of transcription elongation by RNA polymerase II; protein autophosphorylation; and regulation of MAP kinase activity. Located in nuclear speck. Part of cyclin K-CDK12 complex. Biomarker of gastric adenocarcinoma; hepatocellular carcinoma; and stomach cancer. [provided by Alliance of Genome Resources, Mar 2025]","ncbiEntrezGeneId":51755,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/51755","proteins":[{"symbol":"CDK12_HUMAN","href":"/api/1.0/protein/CDK12_HUMAN"}],"hgncRootFamilies":[{"name":"Cyclin-dependent kinases (CDK)","href":"/api/1.0/gene_family/Cyclin-dependent+kinases+%28CDK%29"}]}