{"symbol":"CDK2","synonyms":["CDKN2","P33(CDK2)"],"name":"cyclin-dependent kinase 2","description":"This gene encodes a member of a family of serine/threonine protein kinases that participate in cell cycle regulation. The encoded protein is the catalytic subunit of the cyclin-dependent protein kinase complex, which regulates progression through the cell cycle. Activity of this protein is especially critical during the G1 to S phase transition. This protein associates with and regulated by other subunits of the complex including cyclin A or E, CDK inhibitor p21Cip1 (CDKN1A), and p27Kip1 (CDKN1B). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]","ncbiEntrezGeneId":1017,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1017","proteins":[{"symbol":"CDK2_HUMAN","href":"/api/1.0/protein/CDK2_HUMAN"}],"hgncRootFamilies":[{"name":"Cyclin-dependent kinases (CDK)","href":"/api/1.0/gene_family/Cyclin-dependent+kinases+%28CDK%29"}]}