{"symbol":"CDKN1C","synonyms":["BWCR","KIP2","p57","BWS","P57KIP2"],"name":"cyclin-dependent kinase inhibitor 1C (p57, Kip2)","description":"This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]","ncbiEntrezGeneId":1028,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1028","proteins":[{"symbol":"CDN1C_HUMAN","href":"/api/1.0/protein/CDN1C_HUMAN"}],"hgncRootFamilies":[]}