{"symbol":"CDRT1","synonyms":["C170RF1","C17ORF1A","FBXW10B","FBXW10P1"],"name":"CMT1A duplicated region transcript 1","description":"Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]","ncbiEntrezGeneId":374286,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/374286","proteins":[{"symbol":"CDRT1_HUMAN","href":"/api/1.0/protein/CDRT1_HUMAN"}],"hgncRootFamilies":[{"name":"WD repeat domain containing (WDR)","href":"/api/1.0/gene_family/WD+repeat+domain+containing+%28WDR%29"},{"name":"F-boxes (FBX)","href":"/api/1.0/gene_family/F-boxes+%28FBX%29"}]}