{"symbol":"CELSR2","synonyms":["MEGF3","CDHF10","EGFL2","ADGRC2","FLAMINGO1"],"name":"cadherin, EGF LAG seven-pass G-type receptor 2","description":"The protein encoded by this gene is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":1952,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1952","proteins":[{"symbol":"CELR2_HUMAN","href":"/api/1.0/protein/CELR2_HUMAN"}],"hgncRootFamilies":[{"name":"G protein-coupled receptors","href":"/api/1.0/gene_family/G+protein-coupled+receptors"},{"name":"Cadherins","href":"/api/1.0/gene_family/Cadherins"}]}