{"symbol":"CENPA","synonyms":["CENH3","CENP-A"],"name":"centromere protein A","description":"Centromeres are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. This gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. Centromere protein A is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. The protein is a replication-independent histone that is a member of the histone H3 family. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Nov 2015]","ncbiEntrezGeneId":1058,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1058","proteins":[{"symbol":"CENPA_HUMAN","href":"/api/1.0/protein/CENPA_HUMAN"}],"hgncRootFamilies":[]}