{"symbol":"CENPI","synonyms":["FSHPRH1","MIS6","LRPR1","CENP-I"],"name":"centromere protein I","description":"This gene encodes a centromere protein that is a component of the CENPA-NAC (nucleosome-associated) complex. This complex is critical for accurate chromosome alignment and segregation and it ensures proper mitotic progression. This protein regulates the recruitment of kinetochore-associated proteins that are required to generate the spindle checkpoint signal. The product of this gene is involved in the response of gonadal tissues to follicle-stimulating hormone. Mutations in this gene may be involved in human X-linked disorders of gonadal development and gametogenesis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 13. [provided by RefSeq, Jan 2016]","ncbiEntrezGeneId":2491,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/2491","proteins":[{"symbol":"CENPI_HUMAN","href":"/api/1.0/protein/CENPI_HUMAN"}],"hgncRootFamilies":[]}