{"symbol":"CENPJ","synonyms":["MCPH6","CPAP","BM032","SASS4","CENP-J","SAS-4"],"name":"centromere protein J","description":"This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and cognitive disability. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]","ncbiEntrezGeneId":55835,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/55835","proteins":[{"symbol":"CENPJ_HUMAN","href":"/api/1.0/protein/CENPJ_HUMAN"}],"hgncRootFamilies":[]}