{"symbol":"CEP170","synonyms":["KIAA0470","FAM68A","KAB"],"name":"centrosomal protein 170kDa","description":"The product of this gene is a component of the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. During interphase, the encoded protein localizes to the sub-distal appendages of mature centrioles, which are microtubule-based structures thought to help organize centrosomes. During mitosis, the protein associates with spindle microtubules near the centrosomes. The protein interacts with and is phosphorylated by polo-like kinase 1, and functions in maintaining microtubule organization and cell morphology. The human genome contains a putative transcribed pseudogene. Several alternatively spliced transcript variants of this gene have been found, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":9859,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/9859","proteins":[{"symbol":"CE170_HUMAN","href":"/api/1.0/protein/CE170_HUMAN"}],"hgncRootFamilies":[]}