{"symbol":"CFD","synonyms":["DF","ADIPSIN","PFD","ADN"],"name":"complement factor D (adipsin)","description":"This gene encodes a member of the S1, or chymotrypsin, family of serine peptidases. This protease catalyzes the cleavage of factor B, the rate-limiting step of the alternative pathway of complement activation. This protein also functions as an adipokine, a cell signaling protein secreted by adipocytes, which regulates insulin secretion in mice. Mutations in this gene underlie complement factor D deficiency, which is associated with recurrent bacterial meningitis infections in human patients. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate the mature protease. [provided by RefSeq, Nov 2015]","ncbiEntrezGeneId":1675,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1675","proteins":[{"symbol":"CFAD_HUMAN","href":"/api/1.0/protein/CFAD_HUMAN"}],"hgncRootFamilies":[{"name":"Complement system","href":"/api/1.0/gene_family/Complement+system"}]}