{"symbol":"CFHR1","synonyms":["CFHL1P","CFHL","CFHR1P","HFL2","H36-1","HFL1","FHR1","H36-2","CFHL1"],"name":"complement factor H-related 1","description":"This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq, Oct 2009]","ncbiEntrezGeneId":3078,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/3078","proteins":[{"symbol":"FHR1_HUMAN","href":"/api/1.0/protein/FHR1_HUMAN"}],"hgncRootFamilies":[{"name":"Complement system","href":"/api/1.0/gene_family/Complement+system"}]}