{"symbol":"CFL1","synonyms":["COFILIN","CFL","HEL-S-15"],"name":"cofilin 1 (non-muscle)","description":"The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]","ncbiEntrezGeneId":1072,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1072","proteins":[{"symbol":"COF1_HUMAN","href":"/api/1.0/protein/COF1_HUMAN"}],"hgncRootFamilies":[]}