{"symbol":"CFL2","synonyms":["NEM7"],"name":"cofilin 2 (muscle)","description":"This gene encodes an intracellular protein that is involved in the regulation of actin-filament dynamics. This protein is a major component of intranuclear and cytoplasmic actin rods. It can bind G- and F-actin in a 1:1 ratio of cofilin to actin, and it reversibly controls actin polymerization and depolymerization in a pH-dependent manner. Mutations in this gene cause nemaline myopathy type 7, a form of congenital myopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009]","ncbiEntrezGeneId":1073,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1073","proteins":[{"symbol":"COF2_HUMAN","href":"/api/1.0/protein/COF2_HUMAN"}],"hgncRootFamilies":[]}