{"symbol":"CHD3","synonyms":["MI-2A","MI2-ALPHA","ZFH"],"name":"chromodomain helicase DNA binding protein 3","description":"This gene encodes a member of the CHD family of proteins which are characterized by the presence of chromo (chromatin organization modifier) domains and SNF2-related helicase/ATPase domains. This protein is one of the components of a histone deacetylase complex referred to as the Mi-2/NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromatin remodeling is essential for many processes including transcription. Autoantibodies against this protein are found in a subset of patients with dermatomyositis. Three alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":1107,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1107","proteins":[{"symbol":"CHD3_HUMAN","href":"/api/1.0/protein/CHD3_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}