{"symbol":"CHFR","synonyms":["RNF116","RNF196"],"name":"checkpoint with forkhead and ring finger domains, E3 ubiquitin protein ligase","description":"This gene encodes an E3 ubiquitin-protein ligase required for the maintenance of the antephase checkpoint that regulates cell cycle entry into mitosis and, therefore, may play a key role in cell cycle progression and tumorigenesis. The encoded protein has an N-terminal forkhead-associated domain, a central RING-finger domain, and a cysteine-rich C-terminal region. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Mar 2014]","ncbiEntrezGeneId":55743,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/55743","proteins":[{"symbol":"CHFR_HUMAN","href":"/api/1.0/protein/CHFR_HUMAN"}],"hgncRootFamilies":[{"name":"Zinc fingers","href":"/api/1.0/gene_family/Zinc+fingers"}]}