{"symbol":"CHMP1B","synonyms":["CHMP1.5","HVPS46-2","VPS46-2","VPS46B","C18-ORF2"],"name":"charged multivesicular body protein 1B","description":"CHMP1B belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]","ncbiEntrezGeneId":57132,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/57132","proteins":[{"symbol":"CHM1B_HUMAN","href":"/api/1.0/protein/CHM1B_HUMAN"}],"hgncRootFamilies":[{"name":"Charged multivesicular body proteins (CHMP)","href":"/api/1.0/gene_family/Charged+multivesicular+body+proteins+%28CHMP%29"}]}