{"symbol":"CHMP2A","synonyms":["BC-2","VPS2A","CHMP2","VPS2","BC2"],"name":"charged multivesicular body protein 2A","description":"CHMP2A belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]","ncbiEntrezGeneId":27243,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/27243","proteins":[{"symbol":"CHM2A_HUMAN","href":"/api/1.0/protein/CHM2A_HUMAN"}],"hgncRootFamilies":[{"name":"Charged multivesicular body proteins (CHMP)","href":"/api/1.0/gene_family/Charged+multivesicular+body+proteins+%28CHMP%29"}]}