{"symbol":"CHMP2B","synonyms":["VPS2B","ALS17","CHMP2.5","VPS2-2"],"name":"charged multivesicular body protein 2B","description":"This gene encodes a component of the heteromeric ESCRT-III complex (Endosomal Sorting Complex Required for Transport III) that functions in the recycling or degradation of cell surface receptors. ESCRT-III functions in the concentration and invagination of ubiquitinated endosomal cargos into intralumenal vesicles. The protein encoded by this gene is found as a monomer in the cytosol or as an oligomer in ESCRT-III complexes on endosomal membranes. It is expressed in neurons of all major regions of the brain. Mutations in this gene result in one form of familial frontotemporal lobar degeneration. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":25978,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/25978","proteins":[{"symbol":"CHM2B_HUMAN","href":"/api/1.0/protein/CHM2B_HUMAN"}],"hgncRootFamilies":[{"name":"Charged multivesicular body proteins (CHMP)","href":"/api/1.0/gene_family/Charged+multivesicular+body+proteins+%28CHMP%29"}]}