{"symbol":"CHMP3","synonyms":["CGI-149","NEDF","VPS24"],"name":"charged multivesicular body protein 3","description":"This gene encodes a protein that sorts transmembrane proteins into lysosomes/vacuoles via the multivesicular body (MVB) pathway. This protein, along with other soluble coiled-coil containing proteins, forms part of the ESCRT-III protein complex that binds to the endosomal membrane and recruits additional cofactors for protein sorting into the MVB. This protein may also co-immunoprecipitate with a member of the IFG-binding protein superfamily. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ring finger protein 103 (RNF103) gene. [provided by RefSeq, Nov 2010]","ncbiEntrezGeneId":51652,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/51652","proteins":[{"symbol":"CHMP3_HUMAN","href":"/api/1.0/protein/CHMP3_HUMAN"}],"hgncRootFamilies":[{"name":"Charged multivesicular body proteins (CHMP)","href":"/api/1.0/gene_family/Charged+multivesicular+body+proteins+%28CHMP%29"}]}