{"symbol":"CHMP5","synonyms":["PNAS-2","VPS60","CGI-34","HSPC177","C9ORF83","SNF7DC2"],"name":"charged multivesicular body protein 5","description":"CHMP5 belongs to the chromatin-modifying protein/charged multivesicular body protein (CHMP) family. These proteins are components of ESCRT-III (endosomal sorting complex required for transport III), a complex involved in degradation of surface receptor proteins and formation of endocytic multivesicular bodies (MVBs). Some CHMPs have both nuclear and cytoplasmic/vesicular distributions, and one such CHMP, CHMP1A (MIM 164010), is required for both MVB formation and regulation of cell cycle progression (Tsang et al., 2006 [PubMed 16730941]).[supplied by OMIM, Mar 2008]","ncbiEntrezGeneId":51510,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/51510","proteins":[{"symbol":"CHMP5_HUMAN","href":"/api/1.0/protein/CHMP5_HUMAN"}],"hgncRootFamilies":[{"name":"Charged multivesicular body proteins (CHMP)","href":"/api/1.0/gene_family/Charged+multivesicular+body+proteins+%28CHMP%29"}]}