{"symbol":"CISH","synonyms":["BACTS2","CIS-1","G18","CIS","SOCS"],"name":"cytokine inducible SH2-containing protein","description":"The protein encoded by this gene contains a SH2 domain and a SOCS box domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by IL2, IL3, GM-CSF and EPO in hematopoietic cells. Proteasome-mediated degradation of this protein has been shown to be involved in the inactivation of the erythropoietin receptor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]","ncbiEntrezGeneId":1154,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1154","proteins":[{"symbol":"CISH_HUMAN","href":"/api/1.0/protein/CISH_HUMAN"}],"hgncRootFamilies":[{"name":"SH2 domain containing","href":"/api/1.0/gene_family/SH2+domain+containing"}]}