{"symbol":"CLCF1","synonyms":["NNT-1","BSF-3","CISS2","CLC","BSF3","NNT1"],"name":"cardiotrophin-like cytokine factor 1","description":"This gene is a member of the glycoprotein (gp)130 cytokine family and encodes cardiotrophin-like cytokine factor 1 (CLCF1). CLCF1 forms a heterodimer complex with cytokine receptor-like factor 1 (CRLF1). This dimer competes with ciliary neurotrophic factor (CNTF) for binding to the ciliary neurotrophic factor receptor (CNTFR) complex, and activates the Jak-STAT signaling cascade. CLCF1 can be actively secreted from cells by forming a complex with soluble type I CRLF1 or soluble CNTFR. CLCF1 is a potent neurotrophic factor, B-cell stimulatory agent and neuroendocrine modulator of pituitary corticotroph function. Defects in CLCF1 cause cold-induced sweating syndrome 2 (CISS2). This syndrome is characterized by a profuse sweating after exposure to cold as well as congenital physical abnormalities of the head and spine. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Oct 2009]","ncbiEntrezGeneId":23529,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/23529","proteins":[{"symbol":"CLCF1_HUMAN","href":"/api/1.0/protein/CLCF1_HUMAN"}],"hgncRootFamilies":[]}