{"symbol":"CLEC4G","synonyms":["LSECTIN","UNQ431","DTTR431","LP2698"],"name":"C-type lectin domain family 4, member G","description":"This gene encodes a glycan-binding receptor and member of the C-type lectin family which plays a role in the immune response. C-type lectin receptors are pattern recognition receptors located on immune cells that play a role in the recognition and uptake of both self and non-self glycoproteins as well as mediating cell adhesion, glycoprotein clearance, and cell signaling functions. This gene\u0027s protein binds complex-type N-glycans of the viral envelope proteins of Ebola virus, West Nile filovirus, and SARS coronavirus, but not HIV or hepatitis C virus. In mouse, this protein has been shown to recognize activated T-cells and to negatively regulate T-cell receptor-mediated signalling. It also acts as a novel, liver-specific regulator of NK cell-mediated immunity in mouse. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2020]","ncbiEntrezGeneId":339390,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/339390","proteins":[{"symbol":"CLC4G_HUMAN","href":"/api/1.0/protein/CLC4G_HUMAN"}],"hgncRootFamilies":[{"name":"C-type lectin domain family (CLEC)","href":"/api/1.0/gene_family/C-type+lectin+domain+family+%28CLEC%29"}]}