{"symbol":"CLEC7A","synonyms":["CANDF4","CD369","SCARE2","CLECSF12","BGR","DECTIN1"],"name":"C-type lectin domain family 7, member A","description":"This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with an immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor that recognizes a variety of beta-1,3-linked and beta-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":64581,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/64581","proteins":[{"symbol":"CLC7A_HUMAN","href":"/api/1.0/protein/CLC7A_HUMAN"}],"hgncRootFamilies":[{"name":"CD molecules (CD)","href":"/api/1.0/gene_family/CD+molecules+%28CD%29"},{"name":"C-type lectin domain family (CLEC)","href":"/api/1.0/gene_family/C-type+lectin+domain+family+%28CLEC%29"}]}