{"symbol":"CNR1","synonyms":["CB1","CANN6","CB1R","CB-R","CB1A","CB1K5","CNR"],"name":"cannabinoid receptor 1 (brain)","description":"This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]","ncbiEntrezGeneId":1268,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1268","proteins":[{"symbol":"CNR1_HUMAN","href":"/api/1.0/protein/CNR1_HUMAN"}],"hgncRootFamilies":[{"name":"G protein-coupled receptors","href":"/api/1.0/gene_family/G+protein-coupled+receptors"}]}