{"symbol":"CNTF","synonyms":["HCNTF"],"name":"ciliary neurotrophic factor","description":"The protein encoded by this gene is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. A read-through transcript variant composed of the upstream ZFP91 gene and CNTF sequence has been identified, but it is thought to be non-coding. Read-through transcription of ZFP91 and CNTF has also been observed in mouse. [provided by RefSeq, Oct 2010]","ncbiEntrezGeneId":1270,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1270","proteins":[{"symbol":"CNTF_HUMAN","href":"/api/1.0/protein/CNTF_HUMAN"}],"hgncRootFamilies":[]}