{"symbol":"COMP","synonyms":["PSACH","EPD1","THBS5","EDM1","TSP5"],"name":"cartilage oligomeric matrix protein","description":"The protein encoded by this gene is a noncollagenous extracellular matrix (ECM) protein. It consists of five identical glycoprotein subunits, each with EGF-like and calcium-binding (thrombospondin-like) domains. Oligomerization results from formation of a five-stranded coiled coil and disulfides. Binding to other ECM proteins such as collagen appears to depend on divalent cations. Contraction or expansion of a 5 aa aspartate repeat and other mutations can cause pseudochondroplasia (PSACH) and multiple epiphyseal dysplasia (MED). [provided by RefSeq, Jul 2016]","ncbiEntrezGeneId":1311,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1311","proteins":[{"symbol":"COMP_HUMAN","href":"/api/1.0/protein/COMP_HUMAN"}],"hgncRootFamilies":[]}