{"symbol":"COPS3","synonyms":["SGN3","CSN3"],"name":"COP9 signalosome subunit 3","description":"The protein encoded by this gene possesses kinase activity that phosphorylates regulators involved in signal transduction. It phosphorylates I kappa-Balpha, p105, and c-Jun. It acts as a docking site for complex-mediated phosphorylation. The gene is located within the Smith-Magenis syndrome region on chromosome 17. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]","ncbiEntrezGeneId":8533,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8533","proteins":[{"symbol":"CSN3_HUMAN","href":"/api/1.0/protein/CSN3_HUMAN"}],"hgncRootFamilies":[{"name":"COP9 signalosome  (COPS)","href":"/api/1.0/gene_family/COP9+signalosome++%28COPS%29"}]}