{"symbol":"CORO2A","synonyms":["CLIPINB","IR10","WDR2"],"name":"coronin, actin binding protein, 2A","description":"This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 5 WD repeats, and has a structural similarity with actin-binding proteins: the D. discoideum coronin and the human p57 protein, suggesting that this protein may also be an actin-binding protein that regulates cell motility. Alternative splicing of this gene generates 2 transcript variants. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":7464,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/7464","proteins":[{"symbol":"COR2A_HUMAN","href":"/api/1.0/protein/COR2A_HUMAN"}],"hgncRootFamilies":[{"name":"WD repeat domain containing (WDR)","href":"/api/1.0/gene_family/WD+repeat+domain+containing+%28WDR%29"}]}