{"symbol":"COTL1","synonyms":[],"name":"coactosin-like F-actin binding protein 1","description":"This gene encodes one of the numerous actin-binding proteins which regulate the actin cytoskeleton. This protein binds F-actin, and also interacts with 5-lipoxygenase, which is the first committed enzyme in leukotriene biosynthesis. Although this gene has been reported to map to chromosome 17 in the Smith-Magenis syndrome region, the best alignments for this gene are to chromosome 16. The Smith-Magenis syndrome region is the site of two related pseudogenes. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":23406,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/23406","proteins":[{"symbol":"COTL1_HUMAN","href":"/api/1.0/protein/COTL1_HUMAN"}],"hgncRootFamilies":[]}