{"symbol":"CPAP","synonyms":[],"name":"centrosome assembly and centriole elongation protein","description":"This gene encodes a protein that belongs to the centromere protein family. During cell division, this protein plays a structural role in the maintenance of centrosome integrity and normal spindle morphology, and it is involved in microtubule disassembly at the centrosome. This protein can function as a transcriptional coactivator in the Stat5 signaling pathway, and also as a coactivator of NF-kappaB-mediated transcription, likely via its interaction with the coactivator p300/CREB-binding protein. Mutations in this gene are associated with primary autosomal recessive microcephaly, a disorder characterized by severely reduced brain size and cognitive disability. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Apr 2012]","ncbiEntrezGeneId":55835,"ncbiEntrezGeneUrl":"https://ncbi.nlm.nih.gov/gene/55835","proteins":[],"hgncRootFamilies":[]}