{"symbol":"CPB2","synonyms":["TAFI","CPU"],"name":"carboxypeptidase B2 (plasma)","description":"Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]","ncbiEntrezGeneId":1361,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1361","proteins":[{"symbol":"CBPB2_HUMAN","href":"/api/1.0/protein/CBPB2_HUMAN"}],"hgncRootFamilies":[]}