{"symbol":"CRADD","synonyms":["MRT34","RAIDD"],"name":"CASP2 and RIPK1 domain containing adaptor with death domain","description":"This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with cognitive disability. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]","ncbiEntrezGeneId":8738,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/8738","proteins":[{"symbol":"CRADD_HUMAN","href":"/api/1.0/protein/CRADD_HUMAN"}],"hgncRootFamilies":[]}