{"symbol":"CRISP3","synonyms":["AEG2","DJ442L6.3","CRISP-3","SGP28"],"name":"cysteine-rich secretory protein 3","description":"This gene encodes a member of the cysteine-rich secretory protein (CRISP) family within the CRISP, antigen 5 and pathogenesis-related 1 proteins superfamily. The encoded protein has an N-terminal CRISP, antigen 5 and pathogenesis-related 1 proteins domain, a hinge region, and a C-terminal ion channel regulator domain. This protein contains cysteine residues, located in both the N- and C-terminal domains, that form eight disulfide bonds, a distinguishing characteristic of this family. This gene is expressed in the male reproductive tract where it plays a role in sperm function and fertilization, and the female reproductive tract where it plays a role in endometrial receptivity for embryo implantation. This gene is upregulated in certain types of prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]","ncbiEntrezGeneId":10321,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/10321","proteins":[{"symbol":"CRIS3_HUMAN","href":"/api/1.0/protein/CRIS3_HUMAN"}],"hgncRootFamilies":[]}