{"symbol":"CRK","synonyms":["p38","CRKII"],"name":"v-crk avian sarcoma virus CT10 oncogene homolog","description":"This gene encodes a member of an adapter protein family that binds to several tyrosine-phosphorylated proteins. The product of this gene has several SH2 and SH3 domains (src-homology domains) and is involved in several signaling pathways, recruiting cytoplasmic proteins in the vicinity of tyrosine kinase through SH2-phosphotyrosine interaction. The N-terminal SH2 domain of this protein functions as a positive regulator of transformation whereas the C-terminal SH3 domain functions as a negative regulator of transformation. Two alternative transcripts encoding different isoforms with distinct biological activity have been described. [provided by RefSeq, Jul 2008]","ncbiEntrezGeneId":1398,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1398","proteins":[{"symbol":"CRK_HUMAN","href":"/api/1.0/protein/CRK_HUMAN"}],"hgncRootFamilies":[{"name":"SH2 domain containing","href":"/api/1.0/gene_family/SH2+domain+containing"}]}