{"symbol":"CSE1L","synonyms":["CSE1","XPO2"],"name":"CSE1 chromosome segregation 1-like (yeast)","description":"Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]","ncbiEntrezGeneId":1434,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1434","proteins":[{"symbol":"XPO2_HUMAN","href":"/api/1.0/protein/XPO2_HUMAN"}],"hgncRootFamilies":[{"name":"Exportins (XPO)","href":"/api/1.0/gene_family/Exportins+%28XPO%29"}]}