{"symbol":"CSK","synonyms":[],"name":"c-src tyrosine kinase","description":"The protein encoded by this gene is involved in multiple pathways, including the regulation of Src family kinases. It plays an important role in T-cell activation through its association with the protein encoded by the protein tyrosine phosphatase, non-receptor type 22 (PTPN22) gene. This protein also phosphorylates C-terminal tyrosine residues on multiple substrates, including the protein encoded by the SRC proto-oncogene, non-receptor tyrosine kinase gene. Phosphorylation suppresses the kinase activity of the Src family tyrosine kinases. An intronic polymorphism (rs34933034) in this gene has been found to affect B-cell activation and is associated with systemic lupus erythematosus (SLE). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2017]","ncbiEntrezGeneId":1445,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1445","proteins":[{"symbol":"CSK_HUMAN","href":"/api/1.0/protein/CSK_HUMAN"}],"hgncRootFamilies":[{"name":"SH2 domain containing","href":"/api/1.0/gene_family/SH2+domain+containing"}]}