{"symbol":"CTNND2","synonyms":["GT24","NPRAP"],"name":"catenin (cadherin-associated protein), delta 2","description":"This gene encodes an adhesive junction associated protein of the armadillo/beta-catenin superfamily and is implicated in brain and eye development and cancer formation. The protein encoded by this gene promotes the disruption of E-cadherin based adherens junction to favor cell spreading upon stimulation by hepatocyte growth factor. This gene is overexpressed in prostate adenocarcinomas and is associated with decreased expression of tumor suppressor E-cadherin in this tissue. This gene resides in a region of the short arm of chromosome 5 that is deleted in Cri du Chat syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013]","ncbiEntrezGeneId":1501,"ncbiEntrezGeneUrl":"http://www.ncbi.nlm.nih.gov/gene/1501","proteins":[{"symbol":"CTND2_HUMAN","href":"/api/1.0/protein/CTND2_HUMAN"}],"hgncRootFamilies":[{"name":"Armadillo repeat containing (ARMC)","href":"/api/1.0/gene_family/Armadillo+repeat+containing+%28ARMC%29"}]}